Wednesday, May 18, 2011

Therapeutic Action of Cannabinoids on Multiple Sclerosis

Multiple sclerosis (MS) is a chronic progressive neuro-degenerative disease where the brain and spinal cord are damaged by the gradual destruction of myelin, which is the tissue that covers and protects the brain and spinal cord. Patients who have MS suffer with painful muscle spasms, numbness, impaired vision, loss of balance and coordination, tremors, and weakness. There is currently no known cure for MS.

That being said... DELTA..sup.9-Tetrahydrocannabinol (.DELTA..sup.9-THC), the major psychoactive constituent of marijuana, exerts a broad range of therapeutic effects through its interactions with two cannabinoid (CB) receptor subtypes, CB.sub.1 and CB.sub.2. CB.sub.1 receptors are highly expressed in the central nervous system and to a lesser degree in the periphery in a variety of tissues of the cardiovascular and gastrointestinal systems. By contrast, CB.sub.2 receptors are most abundantly expressed in multiple lymphoid organs and cells of the immune system, including spleen, thymus, tonsils, bone marrow, pancreas and mast cells. (See Link for source)

Many MS patients are using medical marijuana as they have found that it relieves the spasticity, calms tremors, and helps with the depression and anxiety of being ill. There are a number of scientific studies that show that marijuana helps to reduce MS symptoms. One study looked at 167 patients who reported less pain, less muscle spasms, and less bladder incontinence with use of cannabis. These patients reported that they were able to control symptoms with the same dose of cannabis for a mean duration of 434 days without having to increase their dose. (Wade, Multiple Sclerosis 10:425-33, 2004) Researchers suggest that this study demonstrates that marijuana does not lead to increased tolerance requiring increased doses of medication, unlike the conventional medications used to treat MS

Managing the spectrum of pain etiologies remains a major public health problem and both patients and clinicians are seeking improved strategies to effectively manage pain. No currently available therapies or drugs effectively treat all types of nociceptive and neuropathic pain states. The compounds of the present invention are novel CB.sub.2 receptor modulators that have utility in treating pain, including nociceptive and neuropathic pain.

Wednesday, May 4, 2011

Montana: New Montana Medical Marijuana Guidelines

The odious smelling and overtly threatening letters that were sent by the U.S. Attorney in recent weeks to many of the medical marijuana states have left the governor of Montana wringing his hands when he announced he would allow senate bill SB 423 to become law minus his “John Hancock”. Senate bill 423 will majorly inhibit Montana’s blooming medical cannabis industry, closing down approximately 4800 medicinal marijuana collectives and providers, throwing potentially thousands of legally employed people into the dark abyss of unemployment.

In Montana starting July 1 2011, SB 423 will go into effect compelling medical cannabis patients to provide more substantive evidence of qualifying ailment in order to receive a medical cannabis recommendation from a Physician. Once a qualifying patient has been approved and has received a medical cannabis recommendation a patient can cultivate their own medicine or recruit the caregiver who can cultivate for up to three medical marijuana patients and in return must then supply the medicinal cannabis back to the patients at no cost.

New Things to Know and Consider!


Your existing card is still valid until it expires; you’ll renew under the new rules. The same medical conditions will continue to qualify you, but if your diagnosis is “severe chronic pain”, the new law is much more strict. The pain must be persistent and of severe intensity, and objectively proven by an X-ray or MRI, or a second physician must confirm the diagnosis after a physical exam.

You must be a Montana resident.

Once you have your card, if you do not choose a provider, you’ll be able to possess 12 seedlings, 4 mature flowering plants, and 1 ounce of usable marijuana.

By choosing a provider, you give up your right to grow for yourself.

Failure to notify the state of a change of address within 10 days voids your card.

You must carry your medical marijuana card with you at all times.

Parents wishing to register their minor children need a second doctor’s recommendation, must submit fingerprints for an FBI background check, and agree that the minor will never smoke marijuana, only use infused products.

People under department of corrections supervision are not eligible.

Gardens may not be combined and shared, unless you are relatives by blood or marriage.

Drivers may be compelled via search warrant to provide a blood sample. 5ng/ml is cause for a DUI charge.
If your drivers license is revoked for DUI, your medical marijuana card must be surrendered.


A new “provider” registration process is supposed to be available by June 1st, 2011. Anyone who wishes to grow marijuana for someone else will be subject to a fingerprint background check by the FBI, as well as a financial background check (unpaid taxes, student loans, child support).

If you do not get one of the new cards in June, you must bring in all your plants and product to local law enforcement for destruction before July 1st.

You may choose to register as a “marijuana-infused products manufacturer” instead of, or in addition to, registering as a “provider” (grower).

If approved, providers will be allowed to grow 4 mature plants and 12 seedlings each for up to 3 patients.
Nobody can sell anything to anyone. No money, nothing of value may be exchanged for marijuana, except that the patient may reimburse the provider for the state application fee.

Infused product manufacturers must use separate cookware from that which they prepare “normal” food, and are subject to local health department food preparation rules.

You must carry your provider card with you at all times.

Law enforcement will be automatically notified of the location of your garden. You may have only one. Law enforcement can conduct unannounced inspections during business hours.

Gardens cannot be combined or shared.

Must keep a complete set of records showing all transactions with cardholders (by name and ID number), open for inspection by law enforcement at any time during business hours.

Advertising of any kind is prohibited, including via electronic media (websites, email). This provision is effective upon passage — mid-May.

Must describe in writing the medical condition, why it is debilitating, and the extent to which it is debilitating.

Must confirm that they have assumed primary responsibility for caring for the patient.

Must describe the range of other medications and treatments used to treat the condition.

Must confirm that they have reviewed all other medications and supplements and considered their possible interaction with marijuana.

Must confirm they have explained the potential risks of marijuana.

May not affiliate in any way with providers or infused products manufacturers.

May not examine patients where marijuana is being grown.

May not offer a discount or incentive to a patient for choosing a particular provider.

Will be reported to the Board of Medical Examiners if they recommend for more than 25 patients in a year. This will trigger a formal review of the physician’s practices, for which the physician will be responsible for the costs.

Telemedicine recommendations will constitute “unprofessional conduct” under 37-1-316.

Finally, there will be a “hotline” for people to report suspected abuses of the medical marijuana law by anyone, and local governments may ban providers and infused products manufacturers from operating within their boundaries.

If the governor doesn’t veto SB 423, that’s what we have to look forward to.

Don’t Like It?

Contact the governor before May 10th and urge him to veto SB 423:

Click here:
Click here:
Call: (406) 444-3111 and urge the governor to veto SB 423 and regulate medical marijuana via administrative rules.